Majel Barrett Roddenberry has left us.
Majel played the Enterprise's first officer in the original pilot "The Cage" (later recut with a frame story as the TOS two-parter "The Menagerie"), then Nurse Christine Chapel in the original series. Then in TNG she played Councilor Troi's mother, Lwaxana, as well as providing the ubiquitous computer voice in TNG and later series. In fact, she has recenntly finished voice work on the forthcoming Trek movie.
She and Gene Roddenberry married two months after the final episode of Star Trek was aired. (According to Memory Alpha, they were in Japan and has a "Shinto-Buddhist" wedding!)
After Gene's death she did a lot to preserve the Star Trek legacy, and also worked as executive producer on two shows based on ideas from his archives, Earth: Final Conflict and Andromeda.