drug_policy/m.g.extraction.html

From our drug policy file archives. For educational purposes only, to inform the debate about drug policy. Some of the activities discussed here may be illegal, dangerous, stupid, or more than one of the above. (Please note that web links inside this document may be broken.)

Lair of the infamous tms: Drug Policy, m.g.extraction

From mimsy!haven.umd.edu!uunet!zaphod.mps.ohio-state.edu!rpi!usenet.coe. montana.edu!milton!lamontg Sat Dec 7 21:32:08 EST 1991 Article: 21392 of alt.drugs Path: mimsy!haven.umd.edu!uunet!zaphod.mps.ohio-state.edu!rpi!usenet.coe. montana.edu!milton!lamontg From: lamontg@milton.u.washington.edu (Lamont Granquist) Newsgroups: alt.drugs Subject: Re: Seeking advice Message-ID: <1991Dec7.080417.12908@milton.u.washington.edu> Date: 7 Dec 91 08:04:17 GMT References: <6DEC199120555998@rigel.tamu.edu> Organization: Operation: Mindcrime Lines: 125 jwe7206@rigel.tamu.edu writes: > Hello. I was perusing the Anarchist's Cookbook and found the > recipie for making lsd in the kitchen with morning glory seeds, > petroleum ether, and wood alchohol. I've talked with several > people and this method has gotten mixed reviews. Some people > have said this makes you ill and the trips are bad. Has anyone > on here tried this method and what were the results? Also, does > this actually produce lsd 25 or does it make something similar > to psilocybin and peotye. Thanks for your help... All it does is extract the lysergic acid amides from the morning glory seeds. Trust me, the synthesis of LSD from lysergic acid amides is much more complex than your average kitchen chemist is going to be able to pull off (at the very least I think you need a chromatography column). Not only that, but I've seen it posted before (and I certainly find it extremely plausible) that the extraction in the Anarchist's Cookbook is fucked. Here is a method of extraction that I pulled out of _Psychedelic Chemistry_ I haven't tried it, but I give the guy who wrote this more credit that the idiot who wrote the Anarchist's Cookbook... repro w/o permission The occurrence of hallucinogens in the seeds (and to a lesser degree in the leaves and stems) of various members of the family Convolvulaceae (morning glories, etc) was known to the Aztecs. Seeds of the genera _Rivea_, _Impomoea_, and _Argyria_ (Hawaiian baby woodrose) contain lysergic acid derivatives; the woodrose being champion with about one hundred times as much as the other genera (about 7mg alkaloids/g seeds). In view of the low yield (maximum 10mg alkaloids/100g seeds) even the famed pearly gates variety of morning glory is not worthwhile extracting, and the trip is commonly a bummer, resembling that produced by scopolamine or ibogaline and unlike that of LSD. However, the lysergic acid amide, etc., can be extracted, hydrolyzed to lysergic acid (as described below for ergot alkaloid hydrolysis), and converted to LSD by any of the methods described. For species variation of alkaloid content see Lloydia 29,35 (1966). Crude ergot or woodrose seeds should yield ca. 1 g LSD/kg after conversion of the isolated alkaloids. Alkaloid Extraction (short method) Finely grind seeds (preferably woodrose) and add NaHCO3. Extract with ethyl acetate by soaking about one day. Filter and extract the ethyl acetate with tartaric acid solution. Basify the extract with NaHCO3 and extract it with ethyl acetate. Dry and evaporate in vacuum the ethyl acetate to get the alkaloids. Repeat this procedure on the seeds until no more residue is obtained. Alternatively, add 100ml petroleum ether to 100g finely ground seeds and let soak about two days. Filter, discard petroleum ether and let seeds dry. Add 100ml methanol to the seeds and let soak about two days. Filter, repeat extraction with another 100ml methanol and evaporate in vacuum the combined methanol extracts. The residual yellow oil contains the alkaloids. For chromatographic purification of ergot alkaloids from seed extracts see Phytochem. 11,1479 (1972). For ergot extraction and separation see also Fr. Patent 2,089,081 (11 Feb 1972) and Chemical Abstracts 79,105,457 (1973). For a recent review of the ergot alkaloids see R. Manske (Ed.) The Alkaloids, vol. 15:1-40(1975). Extraction of Lysergic Acid Amides from Woodrose Seeds or Powdered Ergot Reduce the seed material to a fine powder in a blender, and spread it out to dry. Grind it again if it is not fine enough after the first time due to dampness. Saturate the powdered seed material with lighter fluid, naptha or ligroine. When completely saturated, it should have the consistency of soup. Pour it on a chromatography column and let it sit overnight. Remove the fatty oils from the material by dripping the ligher fluid or other solvent through the column slowly and keep testing the liquid that comes through for fats by evaporating a drop on clean glass until it leaves no greasy film. It will take several ounces of solvent for each ounce of seeds. Mix 9 volumes of chloroform with 1 volume of concentrated ammonium hydroxide and shake it in a separatory funnel. When it settles the chloroform layer will be on the bottom. Drain off the chloroform layer. Discard the top layer. Drip the chloroform wash through the column and save the extract. Test continuously by evaporating a drop on clean glass until it ceases to flouresce under a black light. Evaporate the chloroform extracts and dissolve the residue in the minimum amount of 3% tartaric acid solution. If all the residue doesn't dissolve, place it into suspension by shaking vigorously. Transfer the solution to a separatory funnel and wash the other vessel with acid in order to get all the alkaloid out. Pour the washings in the funnel also. Basify by adding sodium bicarbonate solution, and add an equal volume of chloroform. Shake this thoroughly, let it settle, remove the bottom layer and set it aside. Once again, add an equal protion of chloroform, shake, let it settle and remove the bottom layer. Combine the chloroform extracts (bottom layers) and evaporate to get the amides. -------- Spelling errors are probably mine. And no, don't even ask about me posting the instructions for synthesis of LSD from lysergic acid alkaloids. Its not easy, and if you're competent and determined enough to pull it off, chances are you can dig up the material yourself (and more importantly I don't feel like typing it in). -- Lamont Granquist Disclaimer: if UW ever finds out what I post... lamontg@u.washington.edu For quotes and other useless info see my .plan alt.drugs FTP site: milton.u.washington.edu[128.95.136.1] dir:/public/alt.drugs

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drug_policy/m.g.extraction.html